The APE1 antibody from MyBioSource.com is a Rabbit Polyclonal antibody to APE1, APEX, APEX1, and APX. This antibody recognizes Human antigen. The APE1 antibody has been validated for the following applications: Immunofluorescence, and Western Blot.
Description
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq]